Investing in regenerative agriculture, the food system, and metabolic health with Carter Williams - iSelect Fund
Fri Feb 06 2026
There is a huge amount we can learn from understanding the connections between soil health, food production, and human metabolic health. Over the last 50-60 years, modern agricultural systems have become increasingly reliant on synthetic inputs that boost yields but degrade soil microbiomes and reduce micronutrient density in our food. This degradation contributes to the chronic disease epidemic costing the United States trillions of dollars annually.
The impact of regenerative agriculture on both environmental and human health cannot be understated. Healthier soils with robust microbiomes produce crops with superior nutritional profiles—more micronutrients and beneficial phytochemicals that express through the soil-plant-human pathway. When people consume these nutrient-dense foods, they show reduced appetite for processed foods and better metabolic outcomes, though randomized controlled trials remain limited.
Today we are joined by Carter Williams from iSelect Fund, a 10-year-old investment firm focused on reducing chronic disease by transforming food systems. Williams coordinates investments across the food value chain—from row crop biologics to novel sweeteners and soil health monitoring.
iSelect Fund targets decommoditizing 5-10% of conventional agriculture rather than wholesale transformation, creating price premiums for regenerative producers while stabilizing markets for conventional farmers. The fund prioritizes nutrient density over yield maximization.
Williams identifies cognitive load as agriculture's fundamental transformation challenge. Farmers with 20 years of conventional experience face learning entirely new systems. This extends throughout supply chains: CPG companies have infrastructure optimized for current grain varieties; input companies have systems built around synthetic fertilizer. Even willing stakeholders face substantial cognitive and financial investment requirements.
The conversation explores modernizing Bureau of Land Management grazing practices. Research showing $200-300 million in upstream regenerative interventions could have prevented $10 billion in European flood insurance losses demonstrates how regenerative livestock management delivers net carbon-positive outcomes while improving rancher economics.
Emerging feedback mechanisms accelerate adoption. Companies like Diatious provide data showing how feeding practices affect omega-3/omega-6 ratios, enabling evidence-based practice changes. Companies like Brightseed build in-silico models mapping how growing practices affect phytochemical expression and human metabolism.
Williams argues consumer voice—amplified by influencers—now drives change more effectively than the previous decade's farmer-led push. As retailers stock out of cottage cheese due to GLP-1 diet trends rather than label-reading, market dynamics shift faster than Nielsen surveys suggested possible.
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There is a huge amount we can learn from understanding the connections between soil health, food production, and human metabolic health. Over the last 50-60 years, modern agricultural systems have become increasingly reliant on synthetic inputs that boost yields but degrade soil microbiomes and reduce micronutrient density in our food. This degradation contributes to the chronic disease epidemic costing the United States trillions of dollars annually. The impact of regenerative agriculture on both environmental and human health cannot be understated. Healthier soils with robust microbiomes produce crops with superior nutritional profiles—more micronutrients and beneficial phytochemicals that express through the soil-plant-human pathway. When people consume these nutrient-dense foods, they show reduced appetite for processed foods and better metabolic outcomes, though randomized controlled trials remain limited. Today we are joined by Carter Williams from iSelect Fund, a 10-year-old investment firm focused on reducing chronic disease by transforming food systems. Williams coordinates investments across the food value chain—from row crop biologics to novel sweeteners and soil health monitoring. iSelect Fund targets decommoditizing 5-10% of conventional agriculture rather than wholesale transformation, creating price premiums for regenerative producers while stabilizing markets for conventional farmers. The fund prioritizes nutrient density over yield maximization. Williams identifies cognitive load as agriculture's fundamental transformation challenge. Farmers with 20 years of conventional experience face learning entirely new systems. This extends throughout supply chains: CPG companies have infrastructure optimized for current grain varieties; input companies have systems built around synthetic fertilizer. Even willing stakeholders face substantial cognitive and financial investment requirements. The conversation explores modernizing Bureau of Land Management grazing practices. Research showing $200-300 million in upstream regenerative interventions could have prevented $10 billion in European flood insurance losses demonstrates how regenerative livestock management delivers net carbon-positive outcomes while improving rancher economics. Emerging feedback mechanisms accelerate adoption. Companies like Diatious provide data showing how feeding practices affect omega-3/omega-6 ratios, enabling evidence-based practice changes. Companies like Brightseed build in-silico models mapping how growing practices affect phytochemical expression and human metabolism. Williams argues consumer voice—amplified by influencers—now drives change more effectively than the previous decade's farmer-led push. As retailers stock out of cottage cheese due to GLP-1 diet trends rather than label-reading, market dynamics shift faster than Nielsen surveys suggested possible. Send us a text