Understanding Histamine Intolerance and MCAS with Michelle Shapiro
Wed Sep 10 2025
Michelle Shapiro is an integrative and functional registered dietitian in New York City who has helped over 1,000 clients reverse their anxiety, heal long-standing gut and immune issues, and approach their weight in a loving way. Michelle has a virtual practice of five nutritionists where she and her team work one-on-one towards these goals. She is the host of the Quiet the Diet podcast, where she helps listeners bridge the gap between body positivity and functional nutrition. She's also the creator of the highly sensitive BodyHub and Information Center for MCAS, POTS, Hypermobility and Long Covid. Together, we discuss histamine intolerance and Mast Cell Activation Syndrome, or MCAS. Michelle gives real-world strategies for understanding and treating histamine intolerance, shares client stories of diagnosis and treatment, and offers valuable clinical and business pearls.
I’m your host, Evelyne Lambrecht, thank you for designing a well world with us.
Episode Resources:
Michelle Shapiro: https://michelleshapirord.com/
Design for Health Resources:
Designs for Health - https://www.designsforhealth.com/
Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/
Visit the Designs for Health Research and Education Library, which houses medical journals, protocols, webinars, and our blog.
https://www.designsforhealth.com/research-and-education/education
The Designs for Health Podcast is produced in partnership with Podfly Productions.
Chapters:
00:00 Intro.
02:38 Michelle’s specialized practice began with two healing crises.
06:37 What goes wrong in Mast Cell Activation Syndrome?
08:46 Overlooked signs that often suggest histamine intolerance.
13:01 Presentation and diagnosis of tell-tale histamine symptoms.
18:22 Addressing symptoms, root causes, and resetting the nervous and immune systems.
22:27 The general client process is always unique and the same.
23:40 Vagus nerve training versus limbic system retraining programs.
28:30 Addressing histamines and systemic inflammation.
29:45 Noticing symptoms appropriately.
34:25 Antihistamine supplement protocol benefits, risks and cognitive issues.
38:28 Supplements, natural antihistamines, detoxes and battle plans.
44:53 Crafting individualized patient treatment plans.
46:55 Low histamine diets, blood sugar stability, and menstrual cycles.
53:55 Pearls for building a business and clientele.
59:38 Michelle’s favorite supplements, favorite health practices, and the body size and composition view that she has changed her mind about.
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Michelle Shapiro is an integrative and functional registered dietitian in New York City who has helped over 1,000 clients reverse their anxiety, heal long-standing gut and immune issues, and approach their weight in a loving way. Michelle has a virtual practice of five nutritionists where she and her team work one-on-one towards these goals. She is the host of the Quiet the Diet podcast, where she helps listeners bridge the gap between body positivity and functional nutrition. She's also the creator of the highly sensitive BodyHub and Information Center for MCAS, POTS, Hypermobility and Long Covid. Together, we discuss histamine intolerance and Mast Cell Activation Syndrome, or MCAS. Michelle gives real-world strategies for understanding and treating histamine intolerance, shares client stories of diagnosis and treatment, and offers valuable clinical and business pearls. I’m your host, Evelyne Lambrecht, thank you for designing a well world with us. Episode Resources: Michelle Shapiro: https://michelleshapirord.com/ Design for Health Resources: Designs for Health - https://www.designsforhealth.com/ Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/ Visit the Designs for Health Research and Education Library, which houses medical journals, protocols, webinars, and our blog. https://www.designsforhealth.com/research-and-education/education The Designs for Health Podcast is produced in partnership with Podfly Productions. Chapters: 00:00 Intro. 02:38 Michelle’s specialized practice began with two healing crises. 06:37 What goes wrong in Mast Cell Activation Syndrome? 08:46 Overlooked signs that often suggest histamine intolerance. 13:01 Presentation and diagnosis of tell-tale histamine symptoms. 18:22 Addressing symptoms, root causes, and resetting the nervous and immune systems. 22:27 The general client process is always unique and the same. 23:40 Vagus nerve training versus limbic system retraining programs. 28:30 Addressing histamines and systemic inflammation. 29:45 Noticing symptoms appropriately. 34:25 Antihistamine supplement protocol benefits, risks and cognitive issues. 38:28 Supplements, natural antihistamines, detoxes and battle plans. 44:53 Crafting individualized patient treatment plans. 46:55 Low histamine diets, blood sugar stability, and menstrual cycles. 53:55 Pearls for building a business and clientele. 59:38 Michelle’s favorite supplements, favorite health practices, and the body size and composition view that she has changed her mind about.