#086 - Richard Miller: There Is No "Mechanism" of Aging
Tue Nov 25 2025
Professor Richard Miller of the University of Michigan, a leading expert in the biology of aging, joins us to redefine what aging is and how we can slow it down.
Discover the groundbreaking work of the Interventions Testing Program (ITP), which has identified over a dozen compounds—including the drug Rapamycin—capable of extending the healthy lifespan of mice by up to 30%. Miller reveals why this level of lifespan extension is considered ten times more effective than finding a complete cure for all adult cancers.
We dive into his revolutionary concept of "Aging Rate Indicators" (the biological "speedometer") and how this new metric is essential for filtering promising anti-aging drugs in mere months, bypassing the need for decades-long clinical trials. Learn why the search for a single "mechanism of aging" is a flawed approach and why widely popular concepts like cellular senescence and telomeres are considered scientific "zombie ideas".
If you're interested in the future of longevity and the science behind the most effective anti-aging drugs, this episode provides an unfiltered look at the cutting edge of biogerontology.
For more information, please see our website: https://www.discoveringacademia.com/episodes/richard-miller
This presentation is a service of Discovering Academia, and all information presented is for commercial and informational purposes only. Discovering Academia provides no assurances as to the accuracy or completeness of the information presented and possesses no actual knowledge of any topic presented. Any opinions expressed in this presentation are solely attributed to each individual asserting the same and do not reflect the opinion of Discovering Academia.
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Professor Richard Miller of the University of Michigan, a leading expert in the biology of aging, joins us to redefine what aging is and how we can slow it down. Discover the groundbreaking work of the Interventions Testing Program (ITP), which has identified over a dozen compounds—including the drug Rapamycin—capable of extending the healthy lifespan of mice by up to 30%. Miller reveals why this level of lifespan extension is considered ten times more effective than finding a complete cure for all adult cancers. We dive into his revolutionary concept of "Aging Rate Indicators" (the biological "speedometer") and how this new metric is essential for filtering promising anti-aging drugs in mere months, bypassing the need for decades-long clinical trials. Learn why the search for a single "mechanism of aging" is a flawed approach and why widely popular concepts like cellular senescence and telomeres are considered scientific "zombie ideas". If you're interested in the future of longevity and the science behind the most effective anti-aging drugs, this episode provides an unfiltered look at the cutting edge of biogerontology. For more information, please see our website: https://www.discoveringacademia.com/episodes/richard-miller This presentation is a service of Discovering Academia, and all information presented is for commercial and informational purposes only. Discovering Academia provides no assurances as to the accuracy or completeness of the information presented and possesses no actual knowledge of any topic presented. Any opinions expressed in this presentation are solely attributed to each individual asserting the same and do not reflect the opinion of Discovering Academia.