S2 E4 How to Start Changing Your Biological Age: Telomere Medicine 2.0
Fri Jan 23 2026
What if the clock you can actually change isn’t on your wrist but inside your cells? We take you into the world of telomeres—the protective caps at the ends of DNA—and show how they reflect your biological age and respond to the choices you make every day. From sleep and nutrition to stress and hormones, we connect the dots between daily habits and the cellular machinery that keeps you sharp, resilient, and strong.
We unpack TA-65, a telomerase activator derived from astragalus root, and explain why it’s drawn attention in longevity medicine. You’ll hear how randomized controlled trials in animals and humans link telomerase activation with longer telomeres, stronger immune function, and improvements in cognition and cardiovascular markers. We also provide essential safety context: GRAS designation, clinical oversight, and why it’s still considered a supplement rather than a prescription therapy. Beyond supplements, we explore how testosterone, estradiol, vitamin D optimization, and carefully supervised peptide protocols may support healthy telomerase activity, while cortisol from unmanaged stress works against it.
Then we zoom into the cellular level to meet TERT, the working engine of telomerase. When oxidative stress hits your mitochondria, TERT can get pulled from the nucleus to play emergency mechanic—leaving telomeres to shorten. That’s why mitochondrial care is central: antioxidant-rich foods, consistent sleep, strength and cardio training, stress tools like meditation and gratitude, and targeted supports such as glutathione, NAD strategies, and even hyperbaric oxygen therapy when appropriate. We outline medications and nutrients that may help (GLP-1s, rosuvastatin, lisinopril, polyphenols, vitamin C, zinc) and highlight the telomerase downsides of frequent NSAID use.
If you want a practical roadmap, we offer the HENSS framework—hormone balance, exercise, nutrition, sleep, and stress management—to build a strong base before layering advanced tools. Ready to measure what matters and act where it counts? Follow the show, share it with a friend, and leave a review telling us which change you’ll start today.
CHECK US OUT ON SOCIAL MEDIA TO SEE WHAT WE ARE UP TO!
FACEBOOK: https://www.facebook.com/NicoleNorrisMD/
INSTAGRAM: Nicole Norris MD Medical Spa (@nicolenorrismd) • Instagram photos and videos
Want to learn more about our concierge preventative medicine programs, longevity medicine services, or fill out an eligibility form?
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What if the clock you can actually change isn’t on your wrist but inside your cells? We take you into the world of telomeres—the protective caps at the ends of DNA—and show how they reflect your biological age and respond to the choices you make every day. From sleep and nutrition to stress and hormones, we connect the dots between daily habits and the cellular machinery that keeps you sharp, resilient, and strong. We unpack TA-65, a telomerase activator derived from astragalus root, and explain why it’s drawn attention in longevity medicine. You’ll hear how randomized controlled trials in animals and humans link telomerase activation with longer telomeres, stronger immune function, and improvements in cognition and cardiovascular markers. We also provide essential safety context: GRAS designation, clinical oversight, and why it’s still considered a supplement rather than a prescription therapy. Beyond supplements, we explore how testosterone, estradiol, vitamin D optimization, and carefully supervised peptide protocols may support healthy telomerase activity, while cortisol from unmanaged stress works against it. Then we zoom into the cellular level to meet TERT, the working engine of telomerase. When oxidative stress hits your mitochondria, TERT can get pulled from the nucleus to play emergency mechanic—leaving telomeres to shorten. That’s why mitochondrial care is central: antioxidant-rich foods, consistent sleep, strength and cardio training, stress tools like meditation and gratitude, and targeted supports such as glutathione, NAD strategies, and even hyperbaric oxygen therapy when appropriate. We outline medications and nutrients that may help (GLP-1s, rosuvastatin, lisinopril, polyphenols, vitamin C, zinc) and highlight the telomerase downsides of frequent NSAID use. If you want a practical roadmap, we offer the HENSS framework—hormone balance, exercise, nutrition, sleep, and stress management—to build a strong base before layering advanced tools. Ready to measure what matters and act where it counts? Follow the show, share it with a friend, and leave a review telling us which change you’ll start today. CHECK US OUT ON SOCIAL MEDIA TO SEE WHAT WE ARE UP TO! FACEBOOK: https://www.facebook.com/NicoleNorrisMD/ INSTAGRAM: Nicole Norris MD Medical Spa (@nicolenorrismd) • Instagram photos and videos Want to learn more about our concierge preventative medicine programs, longevity medicine services, or fill out an eligibility form? Longevity Medicine Testing - Nicole Norris MD - Ottawa, IL GET FIT Get Fit! Weight Management Program | Nicole Norris MD | Peru, IL GET FAB / GET FIRM HORMONE OPTIMIZATION Get Fabulous! Hormone Optimization for Women | Nicole Norris MD Medical Spa Get Firm! Hormone Optimization for Men | Nicole Norris MD Medical Spa Find a Preventative Medicine Provider NEAR YOU! https://www.directory.worldlinkmedical.com/search_results Heart Math for balancing the nervous system and reducing emotional stress- HeartMat...