193. The GLP-1 Revolution: Food Noise, Muscle Loss & The Future of Metabolic Medicine | Priya Jaisinghani, MD
Mon Feb 02 2026
Today, Dr. Priya Jaisinghani joins us to cut through the headlines. We move beyond the "cheating" narrative and explore the biology of obesity as a chronic disease. We discuss the phenomenon of "Food Noise"—the constant mental static about eating—and why silencing it is a matter of brain chemistry, not willpower.
We get into the weeds of patient selection, explaining why BMI is a broken metric (especially for South Asian populations) and why being "skinny" doesn't mean you’re metabolically healthy. We also tackle the serious risks: the "muscle crisis" (sarcopenia), the dangers of unregulated compounding pharmacies, and what happens when you stop these drugs.
What We Discuss:
The "Food Noise" Phenomenon
Patient Selection & The Broken BMI
The Muscle Crisis: Quality vs. Quantity
Safety, Side Effects & The Compounding Trap
The Future of Metabolic Medicine
Resources & Links:
Connect with Dr. Jaisinghani:
NYU Langone Profile: Dr. Priya Jaisinghani
Instagram: @DrJ_NYU
LinkedIn: Priya Jaisinghani, MD
Studies & Literature Mentioned:
SURPASS-3 MRI Sub-study: Reduction in Liver Fat and Muscle Fat with Tirzepatide
SELECT Trial: Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (The "MACE" reduction data)
FLOW Trial: Semaglutide in Patients with Type 2 Diabetes and Chronic Kidney Disease
GRAMS Trial (Upcoming): GLP-1s and Musculoskeletal Outcomes
Medscape Article: Do GLP-1s Have Deleterious Effects on Muscle?
Podcasts & Videos Mentioned:
Podcast: Drug Story by Thomas Goetz (Episode on GLP-1s)
TEDx Talk: Dr. Melanie Jay: Weight Bias in Medicine
Concepts & People:
Dr. Gabrielle Lyon: Muscle-Centric Medicine
Dr. Spencer Nadolski: Lipidologist & Obesity Physician
Want to work with Dr. Raja?
Refining Health & Performance is opening a limited number of founding member spots for the telemedicine practice. We focus on health span, longevity, and performance using a Medicine 3.0 approach. Apply at RefiningHealthRx.com.
Guest Bio:
Dr. Priya Jaisinghani is a triple-board certified physician in Internal Medicine, Endocrinology, and Obesity Medicine, and currently serves as a Clinical Assistant Professor at NYU Grossman School of Medicine.
She completed her training at Weill Cornell and New York-Presbyterian Hospital before becoming a key architect at NYU Langone, where she helped build their official obesity clinical care pathway.
Dr. Jaisinghani is a leading voice in the cardiometabolic space, specializing in the intersection of hormonal health and metabolic dysfunction. She is deeply passionate about treating obesity as a chronic, complex disease rather than a willpower failure.
Beyond her clinical practice, she is a dedicated educator who has secured grant funding to develop tools that teach residents how to dismantle weight bias in the exam room. She serves as a vital bridge between endocrinology, bariatric surgery, and sports medicine to treat the whole patient.
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Today, Dr. Priya Jaisinghani joins us to cut through the headlines. We move beyond the "cheating" narrative and explore the biology of obesity as a chronic disease. We discuss the phenomenon of "Food Noise"—the constant mental static about eating—and why silencing it is a matter of brain chemistry, not willpower. We get into the weeds of patient selection, explaining why BMI is a broken metric (especially for South Asian populations) and why being "skinny" doesn't mean you’re metabolically healthy. We also tackle the serious risks: the "muscle crisis" (sarcopenia), the dangers of unregulated compounding pharmacies, and what happens when you stop these drugs. What We Discuss: The "Food Noise" Phenomenon Patient Selection & The Broken BMI The Muscle Crisis: Quality vs. Quantity Safety, Side Effects & The Compounding Trap The Future of Metabolic Medicine Resources & Links: Connect with Dr. Jaisinghani: NYU Langone Profile: Dr. Priya Jaisinghani Instagram: @DrJ_NYU LinkedIn: Priya Jaisinghani, MD Studies & Literature Mentioned: SURPASS-3 MRI Sub-study: Reduction in Liver Fat and Muscle Fat with Tirzepatide SELECT Trial: Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (The "MACE" reduction data) FLOW Trial: Semaglutide in Patients with Type 2 Diabetes and Chronic Kidney Disease GRAMS Trial (Upcoming): GLP-1s and Musculoskeletal Outcomes Medscape Article: Do GLP-1s Have Deleterious Effects on Muscle? Podcasts & Videos Mentioned: Podcast: Drug Story by Thomas Goetz (Episode on GLP-1s) TEDx Talk: Dr. Melanie Jay: Weight Bias in Medicine Concepts & People: Dr. Gabrielle Lyon: Muscle-Centric Medicine Dr. Spencer Nadolski: Lipidologist & Obesity Physician Want to work with Dr. Raja? Refining Health & Performance is opening a limited number of founding member spots for the telemedicine practice. We focus on health span, longevity, and performance using a Medicine 3.0 approach. Apply at RefiningHealthRx.com. Guest Bio: Dr. Priya Jaisinghani is a triple-board certified physician in Internal Medicine, Endocrinology, and Obesity Medicine, and currently serves as a Clinical Assistant Professor at NYU Grossman School of Medicine. She completed her training at Weill Cornell and New York-Presbyterian Hospital before becoming a key architect at NYU Langone, where she helped build their official obesity clinical care pathway. Dr. Jaisinghani is a leading voice in the cardiometabolic space, specializing in the intersection of hormonal health and metabolic dysfunction. She is deeply passionate about treating obesity as a chronic, complex disease rather than a willpower failure. Beyond her clinical practice, she is a dedicated educator who has secured grant funding to develop tools that teach residents how to dismantle weight bias in the exam room. She serves as a vital bridge between endocrinology, bariatric surgery, and sports medicine to treat the whole patient.