Supercharging a New FDA: Marty Makary on Science, Power & Patients
Mon Jan 19 2026
All-In with Chamath, Jason, Sacks & Friedberg
Key Takeaways Safety remains the FDA’s number one priority, but stifling innovation for “absolute safety” (which can never be achieved) also costs lives The American health establishment must respond with humility when presented with a question it doesn’t know; absolutism is the wrong response The objective of the FDA should not be to fight misinformation – it should be to deliver cures and meaningful treatments faster to the American public and healthier food for children It’s time to stop drugging our nation’s kids at scale because they are antsy from us locking them in LED light boxes all day and shoving processed food in their faces The first step in fixing the health of America’s youth is flipping the food pyramid upside down and focusing on proteinDecades of medical dogma and corruption have put together food pyramids that make no sense; the food industry’s influence on academia caused the inaccurate food pyramids A top goal of the FDA is to reduce drug prices and provide better access to drugs; this will be done by encouraging competition in the marketplace and making more drugs non-prescription Read the full notes @ podcastnotes.org(0:00) Friedberg intros FDA Commissioner Marty Makary
(3:21) Inside the 42 major FDA reforms in 10 months
(7:51) The China Race: Winning back biotech leadership
(13:14) Accelerating drug approvals safely, how to cut down on clinical trial timelines
(33:13) Reshaping the failed Food Pyramid
(41:29) GLP-1s and America's Obesity Epidemic
(49:54) Rethinking vaccines from first principles
(59:40) Lowering drug prices, the power of AI for healthcare
(1:18:57) What causes autism?
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Intro Music Credit:
https://rb.gy/tppkzl
https://x.com/yung_spielburg
Intro Video Credit:
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All-In with Chamath, Jason, Sacks & Friedberg Key Takeaways Safety remains the FDA’s number one priority, but stifling innovation for “absolute safety” (which can never be achieved) also costs lives The American health establishment must respond with humility when presented with a question it doesn’t know; absolutism is the wrong response The objective of the FDA should not be to fight misinformation – it should be to deliver cures and meaningful treatments faster to the American public and healthier food for children It’s time to stop drugging our nation’s kids at scale because they are antsy from us locking them in LED light boxes all day and shoving processed food in their faces The first step in fixing the health of America’s youth is flipping the food pyramid upside down and focusing on proteinDecades of medical dogma and corruption have put together food pyramids that make no sense; the food industry’s influence on academia caused the inaccurate food pyramids A top goal of the FDA is to reduce drug prices and provide better access to drugs; this will be done by encouraging competition in the marketplace and making more drugs non-prescription Read the full notes @ podcastnotes.org(0:00) Friedberg intros FDA Commissioner Marty Makary (3:21) Inside the 42 major FDA reforms in 10 months (7:51) The China Race: Winning back biotech leadership (13:14) Accelerating drug approvals safely, how to cut down on clinical trial timelines (33:13) Reshaping the failed Food Pyramid (41:29) GLP-1s and America's Obesity Epidemic (49:54) Rethinking vaccines from first principles (59:40) Lowering drug prices, the power of AI for healthcare (1:18:57) What causes autism? Follow Marty Makary: https://x.com/DrMakaryFDA Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg Intro Video Credit: https://x.com/TheZachEffect