AI Meets Bitcoin in Singapore — and Why the U.S. Is Back in the Game with Jesse Darnell
Thu Oct 30 2025
The U.S. crypto scene is finally waking up.
After years of regulatory uncertainty and innovation flight, the winds are shifting. Charlie Shrem sits down with Jesse Darnell, former Marine and founder of ADVXNCE Protocol, fresh off Token2049 in Singapore, to talk about why global builders are suddenly turning their eyes back to America.
They dive into:
What Token2049 reveals about the real direction of crypto in Asia
How the U.S. is quietly reopening for crypto innovation — from Wyoming to D.C.
The rise of “AI + Blockchain” startups and why VCs are finally paying attention again
What it means to build a company that’s both community-driven and battle-tested
Lessons from the Marines on leadership, pain, and moving fast in chaos
Why meme coins and serious protocols actually depend on each other
It’s a grounded, hopeful conversation about where the next wave of building will happen — and what it’ll take to win.
Jesse Instagram: https://www.instagram.com/jemappellejesse
Thank you for listening to The Charlie Shrem Show. For more free content and access to over 400 episodes, visit www.CharlieShrem.com.
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The U.S. crypto scene is finally waking up. After years of regulatory uncertainty and innovation flight, the winds are shifting. Charlie Shrem sits down with Jesse Darnell, former Marine and founder of ADVXNCE Protocol, fresh off Token2049 in Singapore, to talk about why global builders are suddenly turning their eyes back to America. They dive into: What Token2049 reveals about the real direction of crypto in Asia How the U.S. is quietly reopening for crypto innovation — from Wyoming to D.C. The rise of “AI + Blockchain” startups and why VCs are finally paying attention again What it means to build a company that’s both community-driven and battle-tested Lessons from the Marines on leadership, pain, and moving fast in chaos Why meme coins and serious protocols actually depend on each other It’s a grounded, hopeful conversation about where the next wave of building will happen — and what it’ll take to win. Jesse Instagram: https://www.instagram.com/jemappellejesse Thank you for listening to The Charlie Shrem Show. For more free content and access to over 400 episodes, visit www.CharlieShrem.com. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.