From Polyphenols to Butyrate: A Clinical Framework for Feeding Keystone Species with Dan Sipple
Thu Feb 05 2026
What if your gut symptoms aren’t about what you’re taking, but who you’re feeding?
Gut change doesn’t start with a supplement aisle sweep. It starts with the small but mighty species running your internal ecosystem. In this episode, functional naturopath Dan Sippel joins us to unpack how keystone bacteria shape gut barrier integrity, immune tolerance and metabolic health, and why the right polyphenols, fibres and bile acids can stabilise a volatile gut without triggering flare-ups.
We explore short-chain fatty acids, especially butyrate, as the microbiome’s currency, influencing inflammation, insulin sensitivity and even brain signaling. Dan shares a laddered strategy for IBS- and SIBO-prone patients: start with low-aggravation polyphenols like pomegranate peel and green tea to lift Akkermansia and Bifidobacterium; introduce partially hydrolysed guar gum as tolerance improves; then progress to resistant starch once the gut lining calms. Along the way, we break down cross-feeding, when direct butyrate makes sense, and why single-strain probiotics only work when you know the strain’s job.
We also dive into bile acids as the missing link in many stuck cases, including constipation, fat maldigestion, hormone symptoms and perimenopause transitions. You’ll learn how dysbiosis disrupts primary-to-secondary bile acid conversion and how to run a practical gut oil change using choleretics, ox bile or TUDCA. Plus, we cover iron repletion without microbiome damage, the role of sleep and melatonin in T-reg signaling, vagal tone support with L-theanine and kava, and a simple daily polyphenol five you can rotate with patients: cacao, blueberries, pomegranate, raw carrot and green tea.
If you’ve cycled through fibres, probiotics and antimicrobials without lasting results, this conversation offers a sequence that sticks. Build the terrain first, protect keystone species, match fibres to the phase, and retest to prove progress as SCFAs rise and inflammation falls.
Connect with Dan: The Functional Naturopath
Shownotes and references are available on the Designs for Health website
Register as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.au
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DISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health
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What if your gut symptoms aren’t about what you’re taking, but who you’re feeding? Gut change doesn’t start with a supplement aisle sweep. It starts with the small but mighty species running your internal ecosystem. In this episode, functional naturopath Dan Sippel joins us to unpack how keystone bacteria shape gut barrier integrity, immune tolerance and metabolic health, and why the right polyphenols, fibres and bile acids can stabilise a volatile gut without triggering flare-ups. We explore short-chain fatty acids, especially butyrate, as the microbiome’s currency, influencing inflammation, insulin sensitivity and even brain signaling. Dan shares a laddered strategy for IBS- and SIBO-prone patients: start with low-aggravation polyphenols like pomegranate peel and green tea to lift Akkermansia and Bifidobacterium; introduce partially hydrolysed guar gum as tolerance improves; then progress to resistant starch once the gut lining calms. Along the way, we break down cross-feeding, when direct butyrate makes sense, and why single-strain probiotics only work when you know the strain’s job. We also dive into bile acids as the missing link in many stuck cases, including constipation, fat maldigestion, hormone symptoms and perimenopause transitions. You’ll learn how dysbiosis disrupts primary-to-secondary bile acid conversion and how to run a practical gut oil change using choleretics, ox bile or TUDCA. Plus, we cover iron repletion without microbiome damage, the role of sleep and melatonin in T-reg signaling, vagal tone support with L-theanine and kava, and a simple daily polyphenol five you can rotate with patients: cacao, blueberries, pomegranate, raw carrot and green tea. If you’ve cycled through fibres, probiotics and antimicrobials without lasting results, this conversation offers a sequence that sticks. Build the terrain first, protect keystone species, match fibres to the phase, and retest to prove progress as SCFAs rise and inflammation falls. Connect with Dan: The Functional Naturopath Shownotes and references are available on the Designs for Health website Register as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.au Follow us on Socials Instagram: Designsforhealthaus Facebook: Designsforhealthaus DISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health