#440 Dr. Christle Guevarra - What’s New In Weight Loss Drugs?
Thu Feb 05 2026
Dr. Christle Guevarra is a board-certified physician in family and sports medicine and an expert in GLP-1 agonist medications and other weight loss drugs.
Christle returns to take us through a deeper dive into the rapidly evolving world of weight loss medications, including new drugs in development, societal implications, influencer narratives, and what patients should actually be thinking about when considering these treatments.
THIS EPISODE COVERS:
Whether there are more effective weight loss drugs on the market than Ozempic
What Tirzepatide is and how it works
What Retatrutide is and whether it is approved for use
What triple receptor agonist medications are
Other promising weight loss medications currently being developed and tested
The potential societal impact of these medications over the next 2 to 5 years
Whether these medications should be used as a long-term solution
What conditions would need to be met to discontinue them
What patients should actively manage about their nutrition while using these medications
Whether there is merit to influencer claims about a “nature’s Ozempic”
New fear-based narratives surrounding GLP-1 agonists and similar drugs
How to navigate conversations around the “skinny Hollywood” trend
And much more
If you would like to hear Christle discuss GLP-1 agonist medications in more foundational detail, check out episode #331:
Apple:
https://podcasts.apple.com/ca/podcast/lift-free-and-diet-hard-with-andrew-coates/id1294990985?i=1000684835291
Spotify:
https://open.spotify.com/episode/6ykUEt7qvn3iWdjLVD3qF7?si=6K_NqyGeQ_6PWeHfYuJ4iQ
YouTube:
https://youtu.be/Q-4ozbqPDGE
Instagram: @dr.christle
CHAPTERS
00:16 Understanding GLP-1 Agonists
00:59 Diving into Tirzepatide
04:15 Cat Vomit Interlude
05:24 RP Strength and Hypertrophy App
06:47 Market and Usage of GLP-1 Agonists
11:41 Future of Weight Loss Medications
21:37 Challenges with Medication Costs
26:59 The Role of Profit in Medical Research
28:09 Long-Term Use of Medications: A Balanced Perspective
31:14 Personal Journey with GLP-1 Medications
33:43 Managing Health Beyond Medication
35:59 Debunking the “Nature’s Ozempic” Myth
39:56 Celebrity Influence and Media Narratives
47:51 Future of Weight Loss Medications
50:24 Resources and Final Thoughts
SUPPORT THE SHOW
If this episode helped clarify the rapidly changing world of weight loss medications, you can support the show by:
Subscribing and checking out more episodes
Sharing it on social media (tag me — I will respond)
Sending it to someone trying to navigate GLP-1 conversations responsibly
FOLLOW ANDREW COATES
Instagram: @andrewcoatesfitness
https://www.andrewcoatesfitness.com
PARTNERS AND RESOURCES
RP Strength App (use code COATESRP)
https://www.rpstrength.com/coates
Just Bite Me Meals (use code ANDREWCOATESFITNESS for 10 percent off)
https://justbitememeals.com/
MacrosFirst – FREE Premium Trial
Download MacrosFirst
During setup, answer: How did you hear about us?
Type: ANDREW
KNKG Bags (15 percent off)
https://www.knkg.com/Andrew59676
Versa Gripps (discount link)
https://www.versagripps.com/andrewcoates
TRAINHEROIC – FREE 90 Day Trial (2 steps)
Go to: https://www.trainheroic.com/liftfree
Reply to the email you receive (or email trials@trainheroic.com
) and let them know Andrew sent you
More
Dr. Christle Guevarra is a board-certified physician in family and sports medicine and an expert in GLP-1 agonist medications and other weight loss drugs. Christle returns to take us through a deeper dive into the rapidly evolving world of weight loss medications, including new drugs in development, societal implications, influencer narratives, and what patients should actually be thinking about when considering these treatments. THIS EPISODE COVERS: Whether there are more effective weight loss drugs on the market than Ozempic What Tirzepatide is and how it works What Retatrutide is and whether it is approved for use What triple receptor agonist medications are Other promising weight loss medications currently being developed and tested The potential societal impact of these medications over the next 2 to 5 years Whether these medications should be used as a long-term solution What conditions would need to be met to discontinue them What patients should actively manage about their nutrition while using these medications Whether there is merit to influencer claims about a “nature’s Ozempic” New fear-based narratives surrounding GLP-1 agonists and similar drugs How to navigate conversations around the “skinny Hollywood” trend And much more If you would like to hear Christle discuss GLP-1 agonist medications in more foundational detail, check out episode #331: Apple: https://podcasts.apple.com/ca/podcast/lift-free-and-diet-hard-with-andrew-coates/id1294990985?i=1000684835291 Spotify: https://open.spotify.com/episode/6ykUEt7qvn3iWdjLVD3qF7?si=6K_NqyGeQ_6PWeHfYuJ4iQ YouTube: https://youtu.be/Q-4ozbqPDGE Instagram: @dr.christle CHAPTERS 00:16 Understanding GLP-1 Agonists 00:59 Diving into Tirzepatide 04:15 Cat Vomit Interlude 05:24 RP Strength and Hypertrophy App 06:47 Market and Usage of GLP-1 Agonists 11:41 Future of Weight Loss Medications 21:37 Challenges with Medication Costs 26:59 The Role of Profit in Medical Research 28:09 Long-Term Use of Medications: A Balanced Perspective 31:14 Personal Journey with GLP-1 Medications 33:43 Managing Health Beyond Medication 35:59 Debunking the “Nature’s Ozempic” Myth 39:56 Celebrity Influence and Media Narratives 47:51 Future of Weight Loss Medications 50:24 Resources and Final Thoughts SUPPORT THE SHOW If this episode helped clarify the rapidly changing world of weight loss medications, you can support the show by: Subscribing and checking out more episodes Sharing it on social media (tag me — I will respond) Sending it to someone trying to navigate GLP-1 conversations responsibly FOLLOW ANDREW COATES Instagram: @andrewcoatesfitness https://www.andrewcoatesfitness.com PARTNERS AND RESOURCES RP Strength App (use code COATESRP) https://www.rpstrength.com/coates Just Bite Me Meals (use code ANDREWCOATESFITNESS for 10 percent off) https://justbitememeals.com/ MacrosFirst – FREE Premium Trial Download MacrosFirst During setup, answer: How did you hear about us? Type: ANDREW KNKG Bags (15 percent off) https://www.knkg.com/Andrew59676 Versa Gripps (discount link) https://www.versagripps.com/andrewcoates TRAINHEROIC – FREE 90 Day Trial (2 steps) Go to: https://www.trainheroic.com/liftfree Reply to the email you receive (or email trials@trainheroic.com ) and let them know Andrew sent you