Inside Matters

Dr Debra Silberg joins Inside Matters for a deep, wide-ranging conversation on gut health, drug development, and the future of microbiome therapeutics. Dr Silberg is the Chief Scientific Officer at Beyond Celiac, a former global clinical leader at Shire/Takeda and AstraZeneca, and one of the most respected figures in GI medicine and microbiome science. In this episode, we explore: • How she moved from basic science to medicine to pharma leadership • Why the GI field needed so much research — and how it transformed • The real science behind ulcers, H. pylori, and the Barry Marshall story • What she teaches in her popular “Understanding Your Gut” course • Prebiotics vs probiotics — what actually matters • The truth about gluten, celiac disease, gluten sensitivity and rising incidence • The microbiome’s role in inflammation, autoimmune disease, mental health & IBS • Whether microbiome drug development is finally turning a corner • Why the gut–brain axis may be the most exciting frontier in medicine Dr Silberg also shares insights from her work with Finch Therapeutics, her role at Beyond Celiac, and her experience advising the team at Biotics. If you’re interested in gut science, the microbiome, diet, or how modern medicines are built from the ground up, you’ll get a huge amount from this conversation. Be well, trust your gut — and thanks for listening. 00:00 Introduction to Dr Debra Silberg 00:54 Dr Silberg's Career Journey 02:26 Insights on Gut Health and Microbiome 04:05 Understanding GI Diseases and Treatments 07:41 The Role of Diet in Gut Health 15:59 Celiac Disease and Gluten Sensitivity 25:04 Exploring the Microbiome 27:43 Exploring Therapeutic Approaches to the Microbiota 31:36 Challenges in Microbiome Drug Development 34:22 The Gut-Brain Connection and Mental Health 39:13 Transitioning from Academia to Pharma 41:45 Insights into Drug Development and Success Stories 44:55 The Long Journey of Drug Development 52:01 The Role of AI in FDA Reviews 55:04 Quick Fire Round: Future of Microbiome Research You must not rely on the information in this video as an alternative to medical advice from your doctor or other professional healthcare provider. If you have any specific questions about any medical matter you should consult your doctor or other professional healthcare provider. If you think you may be suffering from any medical condition you should seek immediate medical attention. You should never delay seeking medical advice, disregard medical advice, or discontinue medical treatment because of the information in this video.