Grand Rounds Dr. Haruki Ishii: Corticosteroid vs. Platelet-Rich Plasma Injections, Part 2
Wed Feb 04 2026
Both corticosteroid injection and PRP demonstrate initial efficacy where steroid appears to provide superior pain relief, as you can see here going down within the first four weeks, whereas PRP demonstrated longer lasting effect, as you can see that the VAS score is actually going down all the way up to 24 weeks, where the corticosteroid injections kind of peak at four weeks, and then slowly the pain comes back to its original level by 24 weeks, maybe around, even like a 12 weeks' time mark. So, both steroid and PRP are considered safe and an effective treatment for the GTPS. But in more recently years, it seems like PRP has a better efficacious indication over CSI for the treatment of GTPS. In a recent system review, it was concluded that PRP seems to be safe and effective when treating degenerative meniscus tears. However, additional studies are warranted. It seems like I'm going to sound like a broken record here, but truly understanding clinical implications of PRP on meniscus treatment due to heterogeneity of the studies reviewed. Similarly, in a recent review, although PRP appears to yield improvements in clinical outcomes. its clinical significance remains uncertain given, again, heterogeneity of the studies. Regarding knee ligament injuries, injection treatment is typically not common for knee ligament related injuries, but injection therapies have a role in reflective cases or when there are significant functional limitations due to pain.
Introduction by Dr. Francis Lopez.
Q&A followed Part 2.
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Both corticosteroid injection and PRP demonstrate initial efficacy where steroid appears to provide superior pain relief, as you can see here going down within the first four weeks, whereas PRP demonstrated longer lasting effect, as you can see that the VAS score is actually going down all the way up to 24 weeks, where the corticosteroid injections kind of peak at four weeks, and then slowly the pain comes back to its original level by 24 weeks, maybe around, even like a 12 weeks' time mark. So, both steroid and PRP are considered safe and an effective treatment for the GTPS. But in more recently years, it seems like PRP has a better efficacious indication over CSI for the treatment of GTPS. In a recent system review, it was concluded that PRP seems to be safe and effective when treating degenerative meniscus tears. However, additional studies are warranted. It seems like I'm going to sound like a broken record here, but truly understanding clinical implications of PRP on meniscus treatment due to heterogeneity of the studies reviewed. Similarly, in a recent review, although PRP appears to yield improvements in clinical outcomes. its clinical significance remains uncertain given, again, heterogeneity of the studies. Regarding knee ligament injuries, injection treatment is typically not common for knee ligament related injuries, but injection therapies have a role in reflective cases or when there are significant functional limitations due to pain. Introduction by Dr. Francis Lopez. Q&A followed Part 2.