Weight Gain on HRT: What’s Really Causing It | Solo
Sat Feb 07 2026
EP. 247: In this episode, I share my honest experience with hormone replacement therapy and unpack why HRT is not a guaranteed weight loss solution. In fact, sometimes it can even lead to weight gain! I walk through how estrogen, progesterone, and testosterone influence appetite, insulin sensitivity, mood, and body composition, and why the wrong balance can sometimes lead to unexpected weight gain. I also explain how oral progesterone affects carb cravings, what is meant by the “Goldilocks” range for estradiol, and why how you feel means more than chasing perfect lab numbers, in my clinical opinion.
Topics Discussed:
→ Does HRT cause weight gain?
→ Why am I gaining weight on progesterone?
→ Can hormone therapy help with menopause symptoms?
→ How estrogen affects metabolism in perimenopause?
→ Is HRT good for insulin resistance?
Sponsored By:
→ Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/DRTYNA and save up to 39% off your Mitopure® Gummies.
→ Cozy Earth | These viral pj’s are so good they sold out during the holidays, and now they’re back with an exclusive deal only available January 25th - February 8th. Head to https://cozyearth.com and use my code DRTYNABOGO to get these pj’s for you and someone you love!
→ Puori | Go to https://puori.com/DRTYNA and use the code DRTYNA at checkout to get 32% off your first Protein subscription order and get a free shaker worth $25.
→ Sundays | Make the switch to Sundays. Go right now to https://sundaysfordogs.com/DRTYNA30 and get 30% off your first 3 orders. Or, you can use code DRTYNA30 at checkout
On This Episode We Cover:
→ 00:00:00 - Introduction
→ 00:00:29 - Dr. Tyna & hormones
→ 00:04:11 - Current hormone routine
→ 00:06:25 - Testosterone & weight gain
→ 00:09:32 - Middle age & weight
→ 00:12:21 - Goldilocks hormone levels
→ 00:19:36 - Estrogen vs progesterone
→ 00:20:22 - Combatting misinformation
→ 00:23:06 - Insulin antagonism
→ 00:27:38 - Transient insulin resistance
→ 00:31:53 - Oral micronized progesterone
→ 00:34:20 - Calories in, calories out
→ 00:36:02 - Estradiol
→ 00:39:30 - Energy storage & insulin resistance
→ 00:45:14 - High hormone levels
→ 00:48:56 - Symptoms to watch for
→ 00:50:27 - Detox & mitochondria
→ 00:51:24 - Muscle & exercise
→ 00:56:21 - “Work harder” & cortisol
→ 01:00:29 - Belly fat & testosterone
Further Listening:
→ EP 163: Understanding The Middle Aged Middle | Solo Episode
Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
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EP. 247: In this episode, I share my honest experience with hormone replacement therapy and unpack why HRT is not a guaranteed weight loss solution. In fact, sometimes it can even lead to weight gain! I walk through how estrogen, progesterone, and testosterone influence appetite, insulin sensitivity, mood, and body composition, and why the wrong balance can sometimes lead to unexpected weight gain. I also explain how oral progesterone affects carb cravings, what is meant by the “Goldilocks” range for estradiol, and why how you feel means more than chasing perfect lab numbers, in my clinical opinion. Topics Discussed: → Does HRT cause weight gain? → Why am I gaining weight on progesterone? → Can hormone therapy help with menopause symptoms? → How estrogen affects metabolism in perimenopause? → Is HRT good for insulin resistance? Sponsored By: → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/DRTYNA and save up to 39% off your Mitopure® Gummies. → Cozy Earth | These viral pj’s are so good they sold out during the holidays, and now they’re back with an exclusive deal only available January 25th - February 8th. Head to https://cozyearth.com and use my code DRTYNABOGO to get these pj’s for you and someone you love! → Puori | Go to https://puori.com/DRTYNA and use the code DRTYNA at checkout to get 32% off your first Protein subscription order and get a free shaker worth $25. → Sundays | Make the switch to Sundays. Go right now to https://sundaysfordogs.com/DRTYNA30 and get 30% off your first 3 orders. Or, you can use code DRTYNA30 at checkout On This Episode We Cover: → 00:00:00 - Introduction → 00:00:29 - Dr. Tyna & hormones → 00:04:11 - Current hormone routine → 00:06:25 - Testosterone & weight gain → 00:09:32 - Middle age & weight → 00:12:21 - Goldilocks hormone levels → 00:19:36 - Estrogen vs progesterone → 00:20:22 - Combatting misinformation → 00:23:06 - Insulin antagonism → 00:27:38 - Transient insulin resistance → 00:31:53 - Oral micronized progesterone → 00:34:20 - Calories in, calories out → 00:36:02 - Estradiol → 00:39:30 - Energy storage & insulin resistance → 00:45:14 - High hormone levels → 00:48:56 - Symptoms to watch for → 00:50:27 - Detox & mitochondria → 00:51:24 - Muscle & exercise → 00:56:21 - “Work harder” & cortisol → 01:00:29 - Belly fat & testosterone Further Listening: → EP 163: Understanding The Middle Aged Middle | Solo Episode Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.