Microdosing for Midlife, Week 1: Intention & Dosage
Tue Feb 03 2026
118. Microdosing for Midlife: Intention Setting, Integration, and Finding Your Dose (Week 1)
Week 1 of Microdosing for Midlife explores intention setting, finding the right microdose, and integrating psilocybin gently during midlife transitions.
Episode Summary
This episode marks Week 1 of Microdosing for Midlife, a 12-week audio series exploring how psilocybin microdosing for women can support emotional awareness, intention, and integration during midlife transitions.
In this opening installment, April Pride reads and expands on the first essay in the series, focused on intention setting and finding the right dose, while grounding the conversation in lived experience. Drawing from her own midlife hormonal transition, grief, and identity shifts, April frames microdosing as an integration practice that unfolds during daily life, rather than something that happens after a peak experience.
The episode introduces why midlife—particularly during perimenopause and emotional regulation shifts—can be a uniquely potent time for this work. Listeners are invited to consider intention not as an outcome-driven goal, but as a present-moment orientation that supports nervous system regulation in midlife and long-term change.
This episode serves as an audio companion to a Substack essay, offering context, reflection, and integration insights that stand on their own without replacing the original written post.
🔵 Key Takeaways
• Why midlife is a neurological, hormonal, and emotional transition• How microdosing supports integration during daily life• Intention setting in microdosing versus goal-setting• Nervous system regulation in midlife• Hormones, neurotransmitters, and emotional resilience• Microdosing protocol safety considerations• Why community-based psychedelic education supports accountability
🔵 Timestamps
[00:00] Series introduction and safety framing[02:00] Why this series is being shared as audio[03:00] Midlife as a period of sovereignty and transformation[04:30] Psychedelic integration practice in real time[05:30] Intention versus goals in microdosing[06:45] Hormones, neurotransmitters, and the midlife brain[07:45] Finding the right microdose and cadence[09:00] Safety considerations before beginning[09:45] Why microdosing should not be done in isolation[11:00] Listener questions and common concerns[12:30] What’s next in the 12-week microdosing series
🔵 Additional Resources
Original Week 1 post on Substack
Episode 72: Preparing for a Psychedelic Journey Safely
Women in the Wild application
Learn more about this episode: https://aprilpride.substack.com/p/microdosing-for-midlife-intention-integration-week-1
Hosted by April Pride
Subscribe for April’s newsletter on Substack at https://aprilpride.substack.com/subscribe or at getsetset.com
Follow on IG: @getsetset / YouTube: youtube.com/@getsetset / X: @getsetset
Get full access to SetSet with April Pride at aprilpride.substack.com/subscribe
More
118. Microdosing for Midlife: Intention Setting, Integration, and Finding Your Dose (Week 1) Week 1 of Microdosing for Midlife explores intention setting, finding the right microdose, and integrating psilocybin gently during midlife transitions. Episode Summary This episode marks Week 1 of Microdosing for Midlife, a 12-week audio series exploring how psilocybin microdosing for women can support emotional awareness, intention, and integration during midlife transitions. In this opening installment, April Pride reads and expands on the first essay in the series, focused on intention setting and finding the right dose, while grounding the conversation in lived experience. Drawing from her own midlife hormonal transition, grief, and identity shifts, April frames microdosing as an integration practice that unfolds during daily life, rather than something that happens after a peak experience. The episode introduces why midlife—particularly during perimenopause and emotional regulation shifts—can be a uniquely potent time for this work. Listeners are invited to consider intention not as an outcome-driven goal, but as a present-moment orientation that supports nervous system regulation in midlife and long-term change. This episode serves as an audio companion to a Substack essay, offering context, reflection, and integration insights that stand on their own without replacing the original written post. 🔵 Key Takeaways • Why midlife is a neurological, hormonal, and emotional transition• How microdosing supports integration during daily life• Intention setting in microdosing versus goal-setting• Nervous system regulation in midlife• Hormones, neurotransmitters, and emotional resilience• Microdosing protocol safety considerations• Why community-based psychedelic education supports accountability 🔵 Timestamps [00:00] Series introduction and safety framing[02:00] Why this series is being shared as audio[03:00] Midlife as a period of sovereignty and transformation[04:30] Psychedelic integration practice in real time[05:30] Intention versus goals in microdosing[06:45] Hormones, neurotransmitters, and the midlife brain[07:45] Finding the right microdose and cadence[09:00] Safety considerations before beginning[09:45] Why microdosing should not be done in isolation[11:00] Listener questions and common concerns[12:30] What’s next in the 12-week microdosing series 🔵 Additional Resources Original Week 1 post on Substack Episode 72: Preparing for a Psychedelic Journey Safely Women in the Wild application Learn more about this episode: https://aprilpride.substack.com/p/microdosing-for-midlife-intention-integration-week-1 Hosted by April Pride Subscribe for April’s newsletter on Substack at https://aprilpride.substack.com/subscribe or at getsetset.com Follow on IG: @getsetset / YouTube: youtube.com/@getsetset / X: @getsetset Get full access to SetSet with April Pride at aprilpride.substack.com/subscribe